LA-14 Probiotic Evidence for Vaginal Microbiome & pH Balance
Lactobacillus acidophilus La-14
Form
Live Probiotic Culture
Source
Healthy Human
Clinically Studied Benefits
- Intimate Health
- Immune Health
- Digestive Health
- Brain Health
Clinical Studies
29
Clinical Human Participants
2037
Recommended Population
- Managing vaginal dryness and pH imbalance caused by estrogen decline.
- Postpartum vaginal microbiome restoration and infection prevention.
Contraindicated Population
Severely immunocompromised patients or individuals with acute vaginal trauma.
Target Health Outcomes
- Restoration of Vaginal Microbiota Balance (increasing Lactobacillus dominance).
- Reduction in the recurrence of Vaginal and Urinary Tract Discomfort.
Mechanism of Action (MoA)
LA-14 Strain →
Oral-to-Vaginal Migration: Survives digestion and migrates to the vaginal tract →
Lactic Acid Production: Lowers local pH to inhibit harmful pathogens →
Bacteriocin Secretion: Produces natural antimicrobial substances (acidophilin) →
Result: Maintains a Healthy Acidic Environment and prevents dysbiosis.
Known Limitations & Uncertainties
- Specificity: Primarily targets Urogenital Health.
- Timing: Best used as a long-term preventive measure rather than an acute treatment for active infections.
- Synergy: Highly effective when combined with HN001 for comprehensive female care.
Related formulas and guides
Explore our probiotic for vaginal microbiome and pH balance, clinical probiotic strain evidence, and women's microbiome support.
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Randomized controlled trial demonstrates response to a probiotic intervention for metabolic syndrome that may correspond to diet
Stanford University
A Healthy Vaginal Microbiota Remains Stable during Oral Probiotic Supplementation: A Randomised Controlled Trial
University of Helsinki
A New Therapy for Uncomplicated Vulvovaginal Candidiasis and Its Impact on Vaginal Flora
University of Trieste
Randomized clinical trial in women with Recurrent Vulvovaginal Candidiasis: Efficacy of probiotics and lactoferrin as maintenance treatment
University of Trieste
Efficacy of vaginal preparation containing Lactobacillus acidophilus, lactic acid and deodorized garlic extract in treatment and prevention of symptomatic bacterial vaginitis: result from a single-arm pilot study
University of Catania
Evidence-based mixture containing Lactobacillus strains and lactoferrin to prevent recurrent bacterial vaginosis: a double blind, placebo controlled, randomised clinical trial
University of Trieste
Study on the effects of an oral lactobacilli and lactoferrin complex in women with intermediate vaginal microbiota
University of Trieste
Lactobacilli vaginal colonisation after oral consumption of Respecta® complex: a randomized controlled pilot study
University of Milan
The Effect of Synbiotic Supplementation on Uremic Toxins, Oxidative Stress, and Inflammation in Hemodialysis Patients—Results of an Uncontrolled Prospective Single-Arm Study
Medical University of Plovdiv
Mixture of probiotics reduces inflammatory biomarkers and improves the oxidative/nitrosative profile in people with rheumatoid arthritis
State University of Londrina
Severe allergic rhinitis, perennial sinusitis and antihistamine dependence resolved with naturopathic treatment: A case study and short literature review
Endeavour College of Natural Health
