Evidence Card
Lacticaseibacillus rhamnosus HN001
Form
Live Probiotic Culture
Source
Cheese
Clinically Studied Benefits
- Intimate Health
- Immune Health
- Digestive Health
- Brain Health
- Metabolic Health
Clinical Studies
92
Clinical Human Participants
16113
Recommended Population
- Postpartum skin sensitivity (eczema/dermatitis) and emotional well-being support.
- Addressing age-related skin barrier decline and "inflammaging."
Contraindicated Population
Severely immunocompromised individuals or those with acute systemic infections.
Target Health Outcomes
- Improvement in Skin Barrier Function and reduction in allergic skin flare-ups.
- Support for Postpartum Mental Wellness (reduction in anxiety/depression scores).
Mechanism of Action (MoA)
HN001 Strain →
Immune Th1/Th2 Balance: Shifts immune response to reduce allergic sensitization →
Gut-Skin Axis: Lowers systemic inflammation that triggers skin redness/itching →
Neuro-Metabolic Signaling: Modulates cytokine pathways linked to mood regulation →
Result: Clearer Skin Texture and improved Emotional Resilience
Known Limitations & Uncertainties
- Focus: Primarily an Female/Immune/Skin/Mood.
- Dosage: Most clinical success seen at 6 billion CFU/day.
- Consistency: Benefits for mood and skin often require long-term use (2–6 months).
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Effect of Lactobacillus rhamnosus HN001 in Pregnancy on Postpartum Symptoms of Depression and Anxiety: A Randomised Double-blind Placebo-controlled Trial
University of Auckland
Effects of Lactobacillus rhamnosus HN001 in early life on the cumulative prevalence of allergic disease to 11 years
University of Otago
Probiotics for the Prevention of Gestational Diabetes Mellitus in Overweight and Obese Women: Findings From the SPRING Double-Blind Randomized Controlled Trial
University of Queensland
Lactobacilli vaginal colonisation after oral consumption of Respecta® complex (HN001/LA-14)
University of Milan
Effects of Lactobacillus rhamnosus HN001 in early life on the cumulative prevalence of allergic disease to 11 years
University of Wellington
A Healthy Vaginal Microbiota Remains Stable during Oral Probiotic Supplementation: A Randomised Controlled Trial
University of Turku
Systemic immunity-enhancing effects in healthy subjects following dietary consumption of the lactic acid bacterium Lactobacillus rhamnosus HN001
Massey University
Early pregnancy probiotic supplementation with Lactobacillus rhamnosus HN001 may reduce the prevalence of gestational diabetes mellitus: a randomised controlled trial
University of Auckland
Efficacy of probiotics and lactoferrin in women with Recurrent Vulvovaginal Candidiasis
University of Otago
Microencapsulation of Lactobacillus rhamnosus HN001 by spray drying and its evaluation under gastrointestinal and storage conditions
Federal University of Uberlândia
