Evidence Card

Bifidobacterium animalis subsp. lactis HN019

Form
Form

Live Probiotic Culture

Source

Dairy

Clinically Studied Benefits
  • Gut Comfort
  • Digestive Health
  • Immune Health
  • Metabolic Health
  • Brain Health
Clinical Studies

68

Clinical Human Participants

11350

Form
Recommended Population

Postpartum constipation and functional bloating due to pelvic floor/lifestyle changes.

Slowed intestinal motility and digestive "heaviness" linked to aging.

Contraindicated Population

Severely immunocompromised individuals or those with acute gastrointestinal obstruction.

Target Health Outcomes
  • Acceleration of Colonic Transit Time:
    Clinically proven to speed up the movement of food through the digestive tract, reducing constipation.
  • Reduction of Functional Gastrointestinal Symptoms:
    Significant decrease in frequency of bloating, abdominal pain, and flatulence.
  • Restoration of Bowel Regularity:
    Improvement in stool consistency and frequency (based on the Bristol Stool Scale).
Mechanism of Action (MoA)

HN019 Strain

Metabolic Interaction: Increases the production of Short-Chain Fatty Acids (SCFAs). →

Peristalsis Stimulation: Modulates signaling to the enteric nervous system to promote gut motility. →

Pathogen Defense: Enhances the intestinal mucosal barrier and outcompetes "bad" bacteria. →

Result: Faster Intestinal Transit and a lighter, comfortable digestive feel.

Evidence Grade
Evidence Type

Human RCT

Meta-analysis

Observational

Animal/In-vitro

Availability

Known Limitations & Uncertainties
  • Dose-Response: Efficacy is highly dose-dependent; higher doses (approx. 10 billion CFU) show significantly faster transit results.
  • Evidence Concentration: Results are most consistent in populations with existing functional constipation.
  • Duration: Improved regularity is typically observed within 14 days of daily consumption.

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