Evidence Card
Lactobacillus acidophilus NCFM
Form
Live Probiotic Culture
Source
Dairy
Clinically Studied Benefits
- Digestive Health
- Gut Comfort
- Lactose Digestion
- Metabolic Health
- Brain Health
- Skin Health
Clinical Studies
113
Clinical Human Participants
9533
Recommended Population
Bloating and "distended belly" caused by perimenopausal hormonal shifts.
Contraindicated Population
Immunocompromised patients or those with severe gut inflammation.
Target Health Outcomes
- Significant reduction in Abdominal Bloating and Belly Distension.
- Relief from Gastrointestinal Discomfort and improvement in bowel regularity.
Mechanism of Action (MoA)
NCFM →
Nerve Signaling: Induces μ-opioid receptors in the gut →
Pain Modulation: Desensitizes the gut to gas pressure and distension →
Microbiome Balance: Suppresses gas-producing bacteria →
Result: Flat stomach (reduced bloating) and abdominal comfort.
Known Limitations & Uncertainties
- Specificity: Most effective for functional bloating; not a cure for chronic inflammatory diseases.
- Dose-Dependency: Optimal effects observed at 1 billion CFU/day or higher.
- Synergy: Combined intake with HN019 often yields better bloating relief.
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An Open-label, Multicenter Study to Assess the Efficacy and Safety of a Novel Probiotic Blend in Patients With Functional Gastrointestinal Symptoms
Mayo Clinic
Lactobacillus acidophilus NCFM affects colonic mucosal opioid receptor expression in patients with functional abdominal pain - a randomised clinical study
UNC Chapel Hill
Probiotic Bacteria L. acidophilus NCFM and B. lactis Bi-07 Versus Placebo for the Symptoms of Bloating
UNC Chapel Hill
Effects of 28-day Bifidobacterium animalis subsp. lactis HN019 supplementation on colonic transit time and gastrointestinal symptoms in adults with functional constipation: A double-blind, randomized, placebo-controlled, and dose-ranging trial
DuPont Nutrition & Health
Dose-response effect of Bifidobacterium lactis HN019 on whole gut transit time and functional gastrointestinal symptoms in adults
Accurate Clinical Research (ACR)
Effect of yogurt containing polydextrose, Lactobacillus acidophilus NCFM and Bifidobacterium lactis HN019: a randomized, double-blind, controlled study in chronic constipation
National Institute of Nutrition (NIN)
Effect of synbiotic in constipated adult women - a randomized, double-blind, placebo-controlled study of clinical response
University of Reading
The effect of a probiotic blend on gastrointestinal symptoms in constipated patients: a double blind, randomised, placebo controlled 2-week trial
University College Cork
Effects of the consumption of Bifidobacterium lactis HN019 (DR10TM) and galacto-oligosaccharides on the microflora of the gastrointestinal tract in human subjects
Massey University
Transcriptional analysis of prebiotic uptake and catabolism by Lactobacillus acidophilus NCFM
North Carolina State University
